Fusion in phospholipid spherical membranes. II. Effect of cholesterol, divalent ions and pH.

@article{Breisblatt1976FusionIP,
  title={Fusion in phospholipid spherical membranes. II. Effect of cholesterol, divalent ions and pH.},
  author={Warren Breisblatt and Shinpei Ohki},
  journal={The Journal of membrane biology},
  year={1976},
  volume={29 1-2},
  pages={127-46}
}
Effect of cholesterol, divalent ions and pH on spherical bilayer membrane fusion was studied as a function of increasing temperature. Spherical bilayer membranes were composed of natural [phosphatidylcholine (PC) and phosphatidylserine (PS)] as well as synthetic (dipalmitoyl-PC, dimyristoyl-PC and dioleoyl-PC) phospholipids. Incorporation of cholesterol into the membrane (33% by weight) suppressed the fusion temperature and also greatly reduced the percentage of membrane fusion. The presence of… CONTINUE READING

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