Fusion from myoblasts to myotubes is dependent on the rolling stone gene (rost) of Drosophila.

@article{Paululat1995FusionFM,
  title={Fusion from myoblasts to myotubes is dependent on the rolling stone gene (rost) of Drosophila.},
  author={Achim Paululat and Susanne Burchard and Renate Renkawitz-Pohl},
  journal={Development},
  year={1995},
  volume={121 8},
  pages={2611-20}
}
The development and differentiation of the body wall musculature in Drosophila are accompanied by changes in gene expression and cellular architecture. We isolated a Drosophila gene, termed rolling stone (rost), which, when mutated, specifically blocks the fusion of mononucleated cells to myotubes in the body wall musculature. beta 3 tubulin, which is an early marker for the onset of mesoderm differentiation, is still expressed in these cells. Gastrulation and mesoderm formation, as well as the… CONTINUE READING
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