Fusion between perinuclear virions and the outer nuclear membrane requires the fusogenic activity of herpes simplex virus gB.

@article{Wright2009FusionBP,
  title={Fusion between perinuclear virions and the outer nuclear membrane requires the fusogenic activity of herpes simplex virus gB.},
  author={Catherine C. Wright and Todd W. Wisner and Brian P. Hannah and Roselyn J Eisenberg and Gary H Cohen and David C. Johnson},
  journal={Journal of virology},
  year={2009},
  volume={83 22},
  pages={11847-56}
}
Herpesviruses cross nuclear membranes (NMs) in two steps, as follows: (i) capsids assemble and bud through the inner NM into the perinuclear space, producing enveloped virus particles, and (ii) the envelopes of these virus particles fuse with the outer NM. Two herpes simplex virus (HSV) glycoproteins, gB and gH (the latter, likely complexed as a heterodimer… CONTINUE READING