Fusing VE-cadherin to α-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation.

Abstract

We have recently shown that genetic replacement of VE-cadherin by a VE-cadherin-α-catenin fusion construct strongly impairs opening of endothelial cell contacts during leukocyte extravasation and induction of vascular permeability in adult mice. Here we show that this mutation leads to lethality at midgestation on a clean C57BL/6 background. Investigating… (More)
DOI: 10.1128/MCB.01526-13

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@article{Dartsch2014FusingVT, title={Fusing VE-cadherin to α-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation.}, author={Nina Dartsch and D{\"o}rte Schulte and Ren{\'e} H{\"a}gerling and Friedemann Kiefer and Dietmar Vestweber}, journal={Molecular and cellular biology}, year={2014}, volume={34 9}, pages={1634-48} }