Fusidic acid in vitro activity.

  title={Fusidic acid in vitro activity.},
  author={Peter J. Collignon and John D. Turnidge},
  journal={International journal of antimicrobial agents},
  volume={12 Suppl 2},
Fusidic acid is a narrow spectrum agent that acts to inhibit protein synthesis by inhibition of elongation factor G at the level of the ribosome. Because of high protein binding susceptibility testing in vitro is affected by the presence of blood or serum. In addition, there is a modest inoculum effect in vitro. A breakpoint of 1 or 2 mg/l is most widely used for defining resistance to systemic treatment with fusidic acid. Fusidic acid activity is principally directed at staphylococci, both… CONTINUE READING

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