Fusidic acid‐resistant EF‐G perturbs the accumulation of ppGpp

@article{Macvanin2000FusidicAE,
  title={Fusidic acid‐resistant EF‐G perturbs the accumulation of ppGpp},
  author={Mirjana Macvanin and Urban Johanson and M{\aa}ns Ehrenberg and David Hughes},
  journal={Molecular Microbiology},
  year={2000},
  volume={37}
}
Reductions in growth rate caused by fusidic acid‐resistant EF‐G mutants in Salmonella typhimurium correlate strongly with increased mean cell size. This is unusual because growth rate and cell size normally correlate positively. The global transcription regulator molecule ppGpp has a role in co‐ordinating growth rate and division, and its basal level normally correlates inversely with cell size at division. We show that fusidic acid‐resistant EF‐G mutants have perturbed ppGpp basal levels… 
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