Fuscoside E: a strong anti-inflammatory diterpene from Caribbean octocoral Eunicea fusca.

@article{Reina2011FuscosideEA,
  title={Fuscoside E: a strong anti-inflammatory diterpene from Caribbean octocoral Eunicea fusca.},
  author={Eduardo Reina and Carlos Puentes and Juan Rojas and Josu{\'e} Garc{\'i}a and Freddy A. Ramos and Leonardo Castellanos and Marcela Arag{\'o}n and Lu{\'i}s Fernando Ospina},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2011},
  volume={21 19},
  pages={
          5888-91
        }
}
The screen of 10 soft coral extracts collected from the Colombian Caribbean Sea in the TPA-induced ear edema model allowed us to identify Eunicea fusca extract among others as an interesting source of active compounds. The new diterpene, fuscoside E (1), along with the known fuscoside B (2), fuscol (3), (+)-germacrene D (4) and a mixture of six sterols (5-10), were isolated from this soft coral. Their structures were elucidated by 1D and 2D NMR spectroscopy techniques. Fuscoside E (1) absolute… 
Fuscoside E: A Strong Antiinflammatory Diterpene from Caribbean Octocoral Eunicea fusca.
A new diterpene, fuscoside E (I), is isolated along with two known fuscosides, (+)-germacrene and a mixture of six known sterols from the Caribbean octocoral Eunicea fusca. The new diterpene (I) and
Trichosanthes dioica Roxb.: A vegetable with diverse pharmacological properties
TLDR
A review of the scientific studies on T. dioica to find the scientific basis of the traditional use to understand the plant’s potential in therapy and to expand the understanding of the therapeutic potential of this species.
In vitro and in vivo anti-inflammatory activity of extracts from a marine mollusc
New drug leads for the treatment of inflammation are urgently needed. The main aim of this thesis was to assess the anti-inflammatory activity of the marine mollusc Dicathais orbita. Lipid extracts
Biofilm inhibition activity of compounds isolated from two Eunicea species collected at the Caribbean Sea
TLDR
Five lipid compounds isolated from soft coral E unicea sp.
Marine Bioactive Compounds from Cnidarians
TLDR
The present work provides an overview of some of the most promising marine bioactive compounds, from a therapeutic point of view, isolated from cnidarians since the year 2000, with emphasis on the sustainable production of target cnids biomass and the role played by symbiotic microorganisms in the synthesis of important biomolecules.
Natural Products from Corals
TLDR
In this section, the research progress on coral-derived MNPs during the past two decades was included, mainly focusing on five points: coral-produced structures with brand-new skeleton, coral- derived MNPs with significant bioactivities, some representative approaches on total synthesis of coral- derive novel compounds, and a short review of the Coral-derived compounds in preclinical and clinical development.
Therapeutic Potential of Essential Oils Focusing on Diterpenes
TLDR
Diterpenes may be an immense featuring concern in pharmaceutical consumption from a drug discovery point of view and take into health‐consumption deportment.
Lessons from the Sea: Distribution, SAR, and Molecular Mechanisms of Anti-inflammatory Drugs from Marine Organisms
TLDR
This chapter will focus on small-molecule drugs obtained from marine animals for the treatment of inflammation, and the distribution of these compounds by different taxonomical families will be discussed, as well as the state-of-the-art regarding their structure–activity relationship.
Propolis Diterpenes as a Remarkable Bio-Source for Drug Discovery Development: A Review
TLDR
This review covers the progress in this arena, with a focus on the chemistry and biological activities of propolis diterpenes, for better understanding of natural product drug discovery research.
Oceans as a Source of Immunotherapy
TLDR
This review focuses on the marine-originated bioactive molecules with immunomodulatory potential, with a particular focus on the molecular mechanisms of specific agents with respect to their targets and the commercial utilization of these compounds for possible drug improvement using metabolic engineering and genomics.
...
1
2
3
...

References

SHOWING 1-10 OF 23 REFERENCES
Fuscosides A-D: anti-inflammatory diterpenoid glycosides of new structural classes from the caribbean gorgonian Eunicea fusca
Four new diterpenoid arabinose glycosides, fuscosides A-D, have been isolated from the Caribbean gorgonian Eunicea fusca Duchassaing and Michelotti. Fuscoside A (1) is a diterpenoid
Estudio químico y evaluación de la actividad antifouling del octocoral caribeño Eunicea laciniata
TLDR
The extract of octocoral Eunicea laciniata organic extract showed antifouling activity against five strains of marine bacteria associated to heavy fouled surfaces and low toxicity in Artemia salina test.
Antiplasmodial metabolites isolated from the marine octocoral Muricea austera.
TLDR
The antiprotozoal activities of the natural compounds 1-8 as well as those of a series of synthetic glycosides and tyramine derivatives were evaluated in vitro against a drug-resistant Plasmodium falciparum and intracellular form of Trypanosoma cruzi.
Fuscoside: an anti-inflammatory marine natural product which selectively inhibits 5-lipoxygenase. Part I: Physiological and biochemical studies in murine inflammatory models.
  • P. Jacobson, R. Jacobs
  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1992
TLDR
These studies represent the first report of an anti-inflammatory marine natural product that selectively inhibits leukotriene biosynthesis and suggest that drug uptake/binding by macrophages is time dependent, saturable and independent of active transport mechanisms.
Cembranoid diterpenes from the Caribbean sea whip Eunicea knighti.
TLDR
Three new cembranoid diterpenes, knightol, knightal, and knightal were isolated as major compounds from the sea whip Eunicea knighti collected from the Colombian Caribbean and showed significant antimicrobial activity against bacterial isolates and excellent anti-QS inhibition activity measured by means of bioluminescence inhibition with biosensor model systems.
Anti-inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of Providencia and San Andrés (SW Caribbean)
TLDR
The results presented contribute to demonstrate that the compounds isolated from P. elisabethae are promising molecules with an interesting anti-inflammatory activity profile, and could provide preliminary insights towards their structure-activity relationship.
New Marine Cembrane Diterpenoids Isolated from the Caribbean Gorgonian Eunicea mammosa
TLDR
Six new cembrane derivatives of α-methylene-δ-lactone derivatives were isolated from the lipid extract of the Caribbean gorgonian Eumicea mammosa, and the structures of these were determined by means of spectroscopic analyses.
Fuscoside: an anti-inflammatory marine natural product which selectively inhibits 5-lipoxygenase. Part II: Biochemical studies in the human neutrophil.
  • P. Jacobson, R. Jacobs
  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1992
TLDR
Fuscoside is representative of a new class of nonantioxidant 5-lipoxygenase inhibitors that may be effective local therapeutic agents in the management of diseases such as psoriasis, arthritis and inflammatory bowel and lung diseases.
Recent developments in anti‐inflammatory natural products
TLDR
The present review article describes anti‐inflammatory natural products derived from plants and marine sources reported during last decade, which belong to different chemical classes such as alkaloids, steroids, terpenoids, polyphenolics, phenylpropanoids, fatty acids and lipids, and various miscellaneous compounds.
A New Prokaryotic Farnesyldiphosphate Synthase from the Octocoral Eunicea Fusca: Differential Display, Inverse PCR, Cloning, and Characterization
TLDR
The cloning of the complete FPPS associated with the E. fusca dinoflagellate symbiont and the amino acid sequence of this FPPS has a high sequence similarity to known archaeal isoprenyl diphosphate synthases, the first description of a prokaryotic FPPS derived from a marine source.
...
1
2
3
...