Fuscoside E: a strong anti-inflammatory diterpene from Caribbean octocoral Eunicea fusca.

@article{Reina2011FuscosideEA,
  title={Fuscoside E: a strong anti-inflammatory diterpene from Caribbean octocoral Eunicea fusca.},
  author={Eduardo Antonio Reina and Carlos Prada Puentes and Juan Leodegario Garc{\'i}a Rojas and Josu{\'e} R. Garc{\'i}a Garc{\'i}a and Freddy Alejandro Ramos and Leonardo Castellanos and Marcela Arag{\'o}n and Lu{\'i}s Fernando Ospina},
  journal={Bioorganic & medicinal chemistry letters},
  year={2011},
  volume={21 19},
  pages={
          5888-91
        }
}
The screen of 10 soft coral extracts collected from the Colombian Caribbean Sea in the TPA-induced ear edema model allowed us to identify Eunicea fusca extract among others as an interesting source of active compounds. The new diterpene, fuscoside E (1), along with the known fuscoside B (2), fuscol (3), (+)-germacrene D (4) and a mixture of six sterols (5-10), were isolated from this soft coral. Their structures were elucidated by 1D and 2D NMR spectroscopy techniques. Fuscoside E (1) absolute… CONTINUE READING
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