Further urinary metabolites of delta 1-tetrahydrocannabinol in man.

  title={Further urinary metabolites of delta 1-tetrahydrocannabinol in man.},
  author={Magnus M Halldin and Lars Andersson and Marianne Widman and Leo E. Hollister},
  volume={32 9},
The in vivo metabolism of delta 1-tetrahydrocannabinol (delta 1-THC) was further investigated in man after oral administration. Five dicarboxylic acids were isolated from the urine and identified by gas chromatography-mass spectrometry. None of these acids have been identified in man before and two of them (3",4",5"-trisnor-delta 1-THC-7,2"-dioic acid (15) and 5"-nor-delta 1-THC-7,4"-dioic acid (17)) have hitherto not been found in any species. The major dicarboxylic acid was 4",5"-bisnor-delta… CONTINUE READING

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