Further upregulation of beta-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice.

@article{Oyama2008FurtherUO,
  title={Further upregulation of beta-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice.},
  author={Takeru Oyama and Yasuhiro Yamada and Kazuya Hata and Hiroyuki Tomita and Akihiro Hirata and Hongqiang Sheng and Akira Hara and Hitomi Aoki and Takahiro Kunisada and Satoshi Yamashita and Hideki Mori},
  journal={Carcinogenesis},
  year={2008},
  volume={29 3},
  pages={666-72}
}
Apc(Min/+) mouse, a mouse model for human familial adenomatosis polyposis, contains a truncating mutation in the Apc gene and spontaneously develops intestinal tumors. Our previous study revealed two distinct stages of tumorigenesis in the colon of Apc(Min/+) mouse: microadenomas and macroscopic tumors. Microadenomas already have lost their remaining allele of the Apc and all microadenomas show accumulation of beta-catenin, indicating that activation of the canonical Wnt pathway is an… CONTINUE READING

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