Further study of anti-ICOS immunotherapy for rat cardiac allograft rejection

To study the effect of B7-CD28 costimulatory signal blockade by adenovirus-mediated cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin (AdCTLA-4Ig) on cardiac allograft survival in DA (RT1a) to LEW (Lewis RT1l) rat combinations. We evaluated the effect of combined AdCTLA-4Ig and anti-inducible costimulator (ICOS) antibody immunotherapy on rat… CONTINUE READING

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