Further studies on the specific infectious agent isolated in rheumatoid arthritis.

@article{Warren1979FurtherSO,
  title={Further studies on the specific infectious agent isolated in rheumatoid arthritis.},
  author={S L Warren and L H Marmor and Heather Horner and W D Stanley and T A Stoeckel and Steve Gerken and G A Patton},
  journal={The Journal of rheumatology},
  year={1979},
  volume={6 2},
  pages={135-46}
}
The active agent in crude or extracted materials from patients with acute rheumatoid arthritis (RA), when injected into embryonated eggs, produced an increased percentage of characteristic "crooked toe" defects in the bioassay. Experimental RA chick materials also produced these defects. A protein-free ribonucleic acid extract from RA synovia and joint fluids of patients with acute or subacute classical RA produced the same experimental RA lesions as did the crude materials, but non-RA… CONTINUE READING