Further studies on the mechanism of action of substance P in rat brain, involving selective phosphatidylinositol hydrolysis


We have suggested that substance P, in cerebral cortex, causes a phosphatidylinositol (PI) breakdown by a dual mechanism suggesting the involvement of either phospholipase A2 or phospholipase C. We have presently characterized further these effects. Substance P (65 pM) provoked an increase in lysoPI concomitant with a decrease in PI level. This finding… (More)
DOI: 10.1007/BF00995377


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