Further studies on the mechanism for the antithrombotic effects of naroparcil, an orally active thiozyloside compound.

  title={Further studies on the mechanism for the antithrombotic effects of naroparcil, an orally active thiozyloside compound.},
  author={P. Masson and J. Theveniaux and D. Coup and T. Gregoire and M. Vaillot and D. Dupouy and P. Si{\'e} and B. Boneu and J. Millet},
  journal={Thrombosis and haemostasis},
  volume={81 6},
The antithrombotic beta-D-xyloside, naroparcil, has previously been shown to induce a dose-related increase of circulating glycosaminoglycans (GAGs) together with an antithrombin activity (anti-IIa) via heparin cofactor II (HCII) in the rabbit. In order to go further in the mechanisms, the relationship between the antithrombotic activity, the HCII-mediated anti-IIa activity and the plasma GAG content was investigated. We showed that the in vitro specific activity on the inhibition of thrombin… Expand
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