Further studies on the antinociceptive effects ofΔ acid

  title={Further studies on the antinociceptive effects of$\Delta$ acid},
  author={Sharon A. Doyle and Sumner H Burstein and William L. Dewey and Sandra P. Welch},
  journal={Agents and Actions},
The antinociceptive effects ofΔ (THC-7-oic) acid have been investigated further with particular regard to the influence of certain experimental parameters in the hot plate test. These included the degree of the thermal stimulus, the nature of the vehicle and a possible role for copper in the response. A temperature effect similar to that seen with nonsteroidalantiinflammatory drugs (NSAIDs) was observed, 55° produced observable antinociception, however, at a surface temperature of 58°C no drug… 

On the Pharmacological Properties of Δ9‐Tetrahydrocannabinol (THC)

Emerging evidence highlights the beneficial effects of the whole cannabis extract over those observed with single components, indicating cannabis‐based medicines as new perspective to revisit the pharmacology of this plant.

Prospects for cannabinoids as anti‐inflammatory agents

  • R. Zurier
  • Biology
    Journal of cellular biochemistry
  • 2003
A portion of the work done by investigators interested in separating the medicinal properties of marijuana from its psychoactive effects is reviewed, finding several marijuana constituents, the carboxylic acid metabolites of tetrahydrocannabinol, and synthetic analogs are free of cannabimimetic central nervous system activity, do not produce behavioral changes in humans, and are effective antiinflammatory and analgesic agents.

The cannabinoid acids, analogs and endogenous counterparts.

  • S. Burstein
  • Chemistry, Biology
    Bioorganic & medicinal chemistry
  • 2014

Cannabinoids for therapeutic use

Water-soluble agonists to the cannabinoid receptor that allow intravenous administration have been developed and Dexanabinol, a non-psychotropic neuroprotective cannabinoid derivative, was given intravenously in clinical studies to decrease the consequences of severe closed head injuries.

Clinical Pharmacokinetics of Cannabinoids

ABSTRACT Absorption and metabolism of tetrahydrocannabinol (THC) vary as a function of route of administration. Pulmonary assimilation of inhaled THC causes a maximum plasma concentration within mi...



Antagonism to the actions of platelet activating factor by a nonpsychoactive cannabinoid.

Findings are suggested that THC-7-oic acid may have considerable activity as an antagonist to platelet activating factor, which may also explain the known properties of THC as a bronchodilator, antipyretic and antirheumatic agent.

Cannabinoids and pain responses: a possible role for prostaglandins

The evidence presented is consistent with a mechanism in which the metabolite inhibits eicosanoid synthesis whereas the parent drug elevates tissue levels of prostaglandins.

Determination of antinociceptive efficacy of drugs in mice using different water temperatures in a tail-immersion test.

  • D. Luttinger
  • Biology, Medicine
    Journal of pharmacological methods
  • 1985

Bioavailability of phenytoin in lipid containing dosage forms in rats

Data may suggest that, in the anaesthetized rat, the depressor response to dopamine may be partly due to the release of a dilator PG, which is not in agreement with those of Dressler, Rossi & Orzechowski (1975) and Pendleton & Woodward (1976) who claimed that indomethacin did not antagonize the renalresponse to dopamine in dogs.

Effect of selected antiinflammatory agents and other drugs on zymosan, arachidonic acid, PAF and carrageenan induced paw edema in the mouse

The inhibitory activities of dual 5-lo/CO inhibitors and NSAIDs were not different in the zymosan, carrageenan and AA edema models in the mouse; however, some selectivity for 5-LO inhibitors was observed in the PAF model.

Prostaglandins and cannabis--XVI. Antagonism of delta 1-tetrahydrocannabinol action by its metabolites.