Further studies on the antinociceptive effects ofΔ acid

  title={Further studies on the antinociceptive effects ofΔ acid},
  author={S. Doyle and S. Burstein and W. Dewey and Sandra P. Welch},
  journal={Agents and Actions},
  • S. Doyle, S. Burstein, +1 author Sandra P. Welch
  • Published 2005
  • Chemistry
  • Agents and Actions
  • The antinociceptive effects ofΔ (THC-7-oic) acid have been investigated further with particular regard to the influence of certain experimental parameters in the hot plate test. These included the degree of the thermal stimulus, the nature of the vehicle and a possible role for copper in the response. A temperature effect similar to that seen with nonsteroidalantiinflammatory drugs (NSAIDs) was observed, 55° produced observable antinociception, however, at a surface temperature of 58°C no drug… CONTINUE READING
    9 Citations

    Figures and Tables from this paper

    Ultrapure ajulemic acid has improved CB2 selectivity with reduced CB1 activity.
    • 28
    Prospects for cannabinoids as anti‐inflammatory agents
    • R. Zurier
    • Medicine
    • Journal of cellular biochemistry
    • 2003
    • 47
    The cannabinoid acids, analogs and endogenous counterparts.
    • S. Burstein
    • Chemistry, Medicine
    • Bioorganic & medicinal chemistry
    • 2014
    • 14
    • PDF
    Cannabinoids for therapeutic use
    • 13
    Clinical Pharmacokinetics of Cannabinoids
    • 33
    • PDF


    Antagonism to the actions of platelet activating factor by a nonpsychoactive cannabinoid.
    • 32
    Cannabinoids and pain responses: a possible role for prostaglandins
    • 35
    Determination of antinociceptive efficacy of drugs in mice using different water temperatures in a tail-immersion test.
    • D. Luttinger
    • Chemistry, Medicine
    • Journal of pharmacological methods
    • 1985
    • 33
    Bioavailability of phenytoin in lipid containing dosage forms in rats
    • 46
    Prostaglandins and cannabis--IX. Stimulation of prostaglandin E2 synthesis in human lung fibroblasts by delta 1-tetrahydrocannabinol.
    • 41
    Prostaglandins and cannabis--XVI. Antagonism of delta 1-tetrahydrocannabinol action by its metabolites.
    • 26
    • Highly Influential