Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys

@article{Woolverton2001FurtherSO,
  title={Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys},
  author={William L. Woolverton and Gerald S. Hecht and Gregory E. Agoston and Jonathan Katz and Amy Hauck Newman},
  journal={Psychopharmacology},
  year={2001},
  volume={154},
  pages={375-382}
}
Rationale: Several halogenated analogs of benztropine (BZT) have previously been characterized as potent DA uptake inhibitors with behavioral profiles that indicate diminished psychomotor stimulant effects relative to cocaine. In a previous study using a fixed-ratio 10 schedule, two chloro-analogs (3′-C1-BZT and 4′-Cl-BZT) maintained IV self-administration in monkeys but appeared to be weak positive reinforcers. Objectives: The present experiments were designed to test the hypothesis that 3′-C1… CONTINUE READING
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