Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys

  title={Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys},
  author={William L. Woolverton and Gerald S. Hecht and Gregory E. Agoston and Jonathan Katz and Amy Hauck Newman},
Rationale: Several halogenated analogs of benztropine (BZT) have previously been characterized as potent DA uptake inhibitors with behavioral profiles that indicate diminished psychomotor stimulant effects relative to cocaine. In a previous study using a fixed-ratio 10 schedule, two chloro-analogs (3′-C1-BZT and 4′-Cl-BZT) maintained IV self-administration in monkeys but appeared to be weak positive reinforcers. Objectives: The present experiments were designed to test the hypothesis that 3′-C1… CONTINUE READING
26 Citations
29 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 26 extracted citations


Publications referenced by this paper.
Showing 1-10 of 29 references

A comparative molecular field analysis ( CoMFA ) study of novel ring - substituted 3 a - ( diphenylmethoxy ) tropane analogs at the dopamine transporter

  • AH Newman, M Robarge, S Izenwasser, RH Kline
  • J Med Chem
  • 1999

Novel dopamine transporter ligands : the state of the art

  • AH Newman
  • Med Chem Res
  • 1998

Dopamine transporter uptake blockers : structure - activity relationships

  • FI Carroll, AH Lewin, MJ Kuhar
  • 1997

Similar Papers

Loading similar papers…