Further pharmacological validation of the BALB/c neophobia in the free exploratory paradigm as an animal model of trait anxiety.

@article{Belzung1997FurtherPV,
  title={Further pharmacological validation of the BALB/c neophobia in the free exploratory paradigm as an animal model of trait anxiety.},
  author={Catherine Belzung and Fernando Berton},
  journal={Behavioural pharmacology},
  year={1997},
  volume={8 6-7},
  pages={
          541-8
        }
}
The present experiments were aimed at investigating the ability of established or putative anxiolytics to reduce the neophobia exhibited by BALB/c mice in the free exploratory paradigm. Results confirm the anxiolytic effects of the benzodiazepine receptor full agonist chlordiazepoxide (2.5-7.5 mg/kg), of meprobamate (15-60 mg/kg) and of ethanol (0.5-1.5 g/kg) and extend the pharmacological action of these compounds to a test situation devoid of anxiogenic components, that is to trait anxiety… CONTINUE READING
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