Further observations on the folate-binding factor in some leukemic cells.

@article{Rothenberg1971FurtherOO,
  title={Further observations on the folate-binding factor in some leukemic cells.},
  author={Sheldon P. Rothenberg and M. J. DaCosta},
  journal={The Journal of clinical investigation},
  year={1971},
  volume={50 3},
  pages={
          719-26
        }
}
The lysates of peripheral cells as well as the serum from some patients with chronic myelogenous leukemia, contained a macromolecular factor which bound tritiated folic acid. Bound tracer folate filtered through Sephadex G-75 and G-100 columns with the early effluent and appeared with the inner volume through a Sephadex G-200 column. Bound tracer could not be extracted from solution by coated charcoal or the anion exchange resin Dowex 2-X8 and could not be reduced to tetrahydrofolate by folate… CONTINUE READING

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