Further observations on the effects of trypsin on the volume and functions of mitochondria isolated from normal liver and AH-130 Yoshida ascites hepatoma.


Evidence is given indicating that the outer membrane of mitochondria from AH-130 Yoshida ascites hepatoma has low resistance to trypsin. The outer membrane of freshly-isolated hepatoma mitochondria is impermeable to cytochrome c and dextran, but it seems to be easily digested by trypsin. The proteolytic enzyme partially inactivates the adenylate kinase and… (More)

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