Corpus ID: 6831747

Further observations on restoration of memory lost after treatment with puromycin.

@article{Flexner1969FurtherOO,
  title={Further observations on restoration of memory lost after treatment with puromycin.},
  author={J. B. Flexner and L. B. Flexner},
  journal={The Yale Journal of Biology and Medicine},
  year={1969},
  volume={42},
  pages={235 - 240}
}
Intracerebral injections of the antibiotic, puromycin dihydrochloride, neutralized with NaOH, cause loss of memory of maze learning in mice."2 This loss persists for at least three months, the longest interval over which we have made retention tests. During the first three days after training in a maze (recent memory), bitemporal injections of the antibiotic, which primarily involve the hippocampal area (hippocampus plus entorhinal cortex), lead to loss of memory. Combined, bilateral temporal… Expand
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References

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Puromycin: Action on Neuronal Mitochondria
Inhibition of Protein Synthesis in vitro by Cycloheximide
Studies on memory: the long survival of peptidyl-puromycin in mouse brain.
  • L. B. Flexner, J. B. Flexner
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1968
Restoration of memory lost after treatment with puromycin
  • Proc. nat. Acad. Sci (Wash.),
  • 1967
Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice.
PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINS.
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  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1964
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