Further observations on LKB1/STK11 status and cancer risk in Peutz–Jeghers syndrome


Germline mutations in the LKB1/STK11 tumour suppressor gene cause Peutz–Jeghers syndrome (PJS), a rare dominant disorder. In addition to typical hamartomatous gastrointestinal polyps and pigmented perioral lesions, PJS is associated with an increased risk of tumours at multiple sites. Follow-up information on carriers is limited and genetic heterogeneity… (More)
DOI: 10.1038/sj.bjc.6601030


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