Further investigations on the effects of ergometrine and other ergot derivatives following injection into the nucleus accumbens of the rat.

@article{Pijnenburg1976FurtherIO,
  title={Further investigations on the effects of ergometrine and other ergot derivatives following injection into the nucleus accumbens of the rat.},
  author={A. J. J. Pijnenburg and William M. Honig and H A Boudier and Alexander Rudolf Cools and Jan A M van der Heyden and J M van Rossum},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1976},
  volume={222 1},
  pages={103-15}
}
The influence of different pretreatments upon locomotor stimulation, induced by injection of ergometrine into the nucleus accumbens of rats, was investigated. The noradrenergic antagonists phenoxybenzamine and propranolol and the serotonin antagonist methysergide produced no clear changes. Reserpine, alone or in combination with alpha-MPT, considerably shortened the delay between injection of ergometrine and start of locomotor stimulation. Ro-DOPA, but not Ro-5-HTP, clearly antagonized the… CONTINUE READING