Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin

@article{Mulder2004FurtherIV,
  title={Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin},
  author={T. B. A. Mulder and Jan B. de Vries and Durk Dijkstra and Johann W. Wiechers and Cor J. Grol and Alan S. Horn},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={336},
  pages={494-501}
}
SummaryThe in vitro binding of the putative dopamine autoreceptor agonist [3H]DP-7-ATN to rat striatal membrane homogenates was investigated. The maximum number of binding sites Bmax was 497.5 ± 50.2 fmol/mg protein and the affinity constant KD was 8.3 ± 1.5 nM using 10 μM (+) butaclamol to define non-specific binding. Lesion of the left medium forebrain bundle by 6-hydroxydopamine resulted in an almost complete loss of dopamine in the striatum but did not affect the binding of [3H]DP-7-ATN… 
Behavioural effects in the rat of the putative dopamine D3 receptor agonist 7-OH-DPAT: comparison with quinpirole and apomorphine
TLDR
Together, the data suggest that the putative dopamine D3 agonist 7-OH-DPAT, at low doses, has depressant effects similar to those induced by low doses of the other two DA agonists.
Upregulation of (+)-7-Hydroxy-N,N-di-n-[3H]Propyl-2-Aminotetralin Binding Following Intracerebroventricular Administration of a Nitric Oxide Generator
TLDR
D3 receptor density is modified following nitric oxide generation, and the density of high affinity D2 receptors identified by [3H](+)-7-OH-DPAT increases in the striatum, but decreases in the nucleus accumbens.
Characterization of binding sites for [125I]R(+)trans-7-OH-PIPAT in rat brain
TLDR
[125I]R(+)trans-7-OH-PIPAT offers several unique advantages, including high specific activity and high affinity binding, which make it an excellent probe for the investigation and characterization of the distribution of dopamine D 3 receptors.

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