Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin

  title={Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin},
  author={T. Mulder and J. Vries and D. Dijkstra and J. Wiechers and C. J. Grol and A. Horn},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  • T. Mulder, J. Vries, +3 authors A. Horn
  • Published 2004
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • SummaryThe in vitro binding of the putative dopamine autoreceptor agonist [3H]DP-7-ATN to rat striatal membrane homogenates was investigated. The maximum number of binding sites Bmax was 497.5 ± 50.2 fmol/mg protein and the affinity constant KD was 8.3 ± 1.5 nM using 10 μM (+) butaclamol to define non-specific binding. Lesion of the left medium forebrain bundle by 6-hydroxydopamine resulted in an almost complete loss of dopamine in the striatum but did not affect the binding of [3H]DP-7-ATN… CONTINUE READING
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