Further evidence that propentofylline (HWA 285) influences both adenosine receptors and adenosine transport

@article{Fredholm1992FurtherET,
  title={Further evidence that propentofylline (HWA 285) influences both adenosine receptors and adenosine transport},
  author={B. Fredholm and J. Fastbom and A. Kvanta and P. Gerwins and F. Parkinson},
  journal={Fundamental \& Clinical Pharmacology},
  year={1992},
  volume={6}
}
Summary— We have examined the actions of a novel xanthine derivative, propentofylline (HWA 285), that has been shown to protect against ischemic brain damage in rats and gerbils, on adenosine receptors (A1 and A2), and on adenosine transporters using several techniques, cells and tissues. Propentofylline and its hydroxylated metabolite A 72 0287 were about 20 times less potent than theophylline in displacing A1‐agonist binding to membranes from rat cortex, and A1‐antagonist binding to whole DDT… Expand
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