Further evidence that naloxone acts as an inverse opiate agonist: implications for drug dependence and withdrawal.

@article{Cruz1996FurtherET,
  title={Further evidence that naloxone acts as an inverse opiate agonist: implications for drug dependence and withdrawal.},
  author={Silvia Lorenia Cruz and Jul{\'i}an E. Villarreal and Nora D. Volkow},
  journal={Life sciences},
  year={1996},
  volume={58 26},
  pages={PL381-9}
}
To test if naloxone behaved as an inverse agonist rather than as an antagonist we evaluated its responses in guinea-pig ilea with and without morphine (480 nM, 24 h). In control ilea, naloxone (100 nM) had no effect. In morphine-treated ilea, naloxone as a bolus, but not as an infusion, elicited an abstinence response. Preadministration of naloxone blocked the response to subsequent administrations. Similarly, naloxone failed to produce an abstinence response in ilea pretreated with kappa… CONTINUE READING

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