Further evidence of the trypanocidal action of eupomatenoid-5: confirmation of involvement of reactive oxygen species and mitochondria owing to a reduction in trypanothione reductase activity.

@article{LazarinBidia2013FurtherEO,
  title={Further evidence of the trypanocidal action of eupomatenoid-5: confirmation of involvement of reactive oxygen species and mitochondria owing to a reduction in trypanothione reductase activity.},
  author={Danielle Lazarin-Bid{\'o}ia and V{\^a}nia Cristina Desoti and T{\^a}nia Ueda-Nakamura and Benedito Prado Dias Filho and Celso Vataru Nakamura and Sueli de Oliveira Silva},
  journal={Free radical biology & medicine},
  year={2013},
  volume={60},
  pages={17-28}
}
Our group assays natural products that are less toxic and more effective than available nitroheterocycles as promising therapeutic options for patients with Chagas disease. Our previous study reported the trypanocidal activity of eupomatenoid-5, a neolignan isolated from the leaves of Piper regnellii var. pallescens, against the three main parasitic forms of Trypanosoma cruzi. The present study further characterizes the biochemical and morphological alterations induced by this compound to… CONTINUE READING
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