Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointes.

@article{Lehtonen2007FurtherEO,
  title={Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointes.},
  author={Annukka Lehtonen and Heidi Fodstad and P{\"a}ivi J Laitinen-Forsblom and Lauri Toivonen and Kimmo K. Kontula and Heikki Swan},
  journal={Heart rhythm},
  year={2007},
  volume={4 5},
  pages={603-7}
}
BACKGROUND Pathophysiologically significant ion-channel mutations have been detected in only a minority of cases of acquired long QT syndrome (LQTS). OBJECTIVE The aim of this study was to clarify the putative role of subclinical inherited LQTS in drug-associated torsades de pointes (TdP) and to assess the concomitant proarrhythmic factors. METHODS We evaluated 16 consecutive cases with documented, antiarrhythmic drug-induced TdP who were referred to the Laboratory of Molecular Medicine at… CONTINUE READING

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