Further evidence of association between two NET single-nucleotide polymorphisms with ADHD

@article{Kim2008FurtherEO,
  title={Further evidence of association between two NET single-nucleotide polymorphisms with ADHD},
  author={J. W. Kim and Joseph Biederman and Casey McGrath and Alysa E. Doyle and Eric O. Mick and Jesen A. Fagerness and Shaun M Purcell and J. W. Smoller and Pamela Sklar and S.V. Faraone},
  journal={Molecular Psychiatry},
  year={2008},
  volume={13},
  pages={624-630}
}
The norepinephrine transporter (NET) gene is an attractive candidate gene for attention-deficit hyperactivity disorder (ADHD). Noradrenergic systems are critical to higher brain functions such as attention and executive function, which are defective in ADHD. The clinical efficacy of medications that target NET also supports its role in the etiology of ADHD. Here, we have applied a dense mapping strategy to capture all genetic variations within the NET gene in a large number of ADHD families… 

Differential association between the norepinephrine transporter gene and ADHD: role of sex and subtype.

It is suggested that haplotype blocks within different regions of SLC6A2 show differential association with the disorder based on sex and subtype, which may have been masked in previous studies when tests were conducted with pooled samples.

No evidence for association between a functional promoter variant of the Norepinephrine Transporter gene SLC6A2 and ADHD in a family-based sample

It is concluded that A-3081T is not a major risk variant in the ADHD sample, though SLC6A2 remains an interesting candidate gene in ADHD, especially for the inattentive subtype.

Replication of a rare protective allele in the noradrenaline transporter gene and ADHD

  • X. XuZ. Hawi P. Asherson
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
The data were consistent for rs11568324, suggesting the existence of a rare allele conferring protection for ADHD within the SLC6A2 gene, and further investigations should focus on identifying the mechanisms underlying the protective effect.

Association studies of −3081(A/T) polymorphism of norepinephrine transporter gene with attention deficit/hyperactivity disorder in Korean population

  • Y. JoungChun-Hyung Kim Kwang-Soo Kim
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2010
Evidence is provided of association between ADHD and −3081(A/T) polymorphism of SLC6A2 and significant differences were found in the allele frequencies and odds ratio suggesting that T allele is critical to make the group difference.

Case-Control Association Study of the Norepinephrine Transporter Gene Polymorphism in Children with ADHD

A study examining the association between norepinephrine transporter gene (SLC6A2) poly-morphisms and attention-deficit hyperactivity disorder (ADHD) and results of the Korean version of the parent ADHD rating scale (K-ARS) found no significant evidence of an association.

A Haplotype of the Norepinephrine Transporter (Net) Gene Slc6a2 is Associated with Clinical Response to Atomoxetine in Attention-Deficit Hyperactivity Disorder (ADHD)

It is suggested that further assessment of the genomic region across exons 4 to 9 of NET/SLC6A2, where 36 SNPs have been genotyped, could be useful in determining response to atomoxetine in ADHD.

Comprehensive Phenotype/Genotype Analyses of the Norepinephrine Transporter Gene (SLC6A2) in ADHD: Relation to Maternal Smoking during Pregnancy

By using maternal smoking during pregnancy to index a putatively more homogeneous group of ADHD, highly significant associations were observed between tag SNPs within SLC6A2 and ADHD diagnosis, behavioral and cognitive measures relevant to ADHD and response to MPH.

The possible involvement of genetic variants of NET1 in the etiology of attention-deficit/hyperactivity disorder comorbid with oppositional defiant disorder.

NET1 was associated with comorbidity of ODD and ODD symptoms in ADHD probands, especially with 'Argumentative/Defiant Behavior (ADB)' dimension after controlling gender, age, clinical subtypes and intelligence.
...

References

SHOWING 1-10 OF 42 REFERENCES

No evidence of linkage or association between the norepinephrine transporter (NET) gene MnlI polymorphism and adult ADHD

  • V. De LucaP. MugliaU. JainJ. Kennedy
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2004
Investigation for the presence of linkage disequilibrium between the MnlI RFLP in the NET gene and adult ADHD in a sample of nuclear families found no preferential transmission of either allele.

DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: No evidence for association

  • Xiaohui XuJ. Knight P. Asherson
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2005
Investigating whether common polymorphisms within the norepinephrine transporter gene (NET1) are associated with DSM‐IV ADHD combined subtype concludes that none of the markers show significant evidence of association with ADHD although it cannot rule out small genetic effects.

The norepinephrine transporter gene and attention-deficit hyperactivity disorder.

The results do not support the NET1 gene as a major genetic susceptibility factor in ADHD.

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes

Examining single-nucleotide polymorphisms spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1.

Support for association between ADHD and two candidate genes: NET1 and DRD1

  • A. BobbA. Addington J. Rapoport
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2005
Support is provided for an association between ADHD and polymorphisms in both NET1 and DRD1; polymorphismsIn ten other candidate genes were not associated with ADHD.

Molecular genetics of attention deficit hyperactivity disorder.

Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.

A study of 76 candidate genes has identified brain-derived neurotrophic factor (BDNF) as a potential risk allele that will require additional study to confirm.

Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes.

Genotypic information from 14 independent samples of probands and their parents and joint analysis showed association with the DRD5 locus, and this association appears to be confined to the predominantly inattentive and combined clinical subtypes.

Genetics of childhood disorders: XIX. ADHD, Part 3: Is ADHD a noradrenergic disorder?

  • J. BiedermanT. Spencer
  • Biology, Psychology
    Journal of the American Academy of Child and Adolescent Psychiatry
  • 2000
Current neuropsychological, genetic, imaging, and pharmacological data emerging in ADHD research provide compelling support for a noradrenergic hypothesis of ADHD.

Association of norepinephrine transporter gene with methylphenidate response.

Findings suggest an association between the G1287A polymorphism of the norepinephrine transporter gene and variation in methylphenidate response is found in Chinese Han youths with attention-deficit/hyperactivity disorder.