Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: the Hypertension Genetic Epidemiology Network (HyperGEN) Study.

@article{Pankow2005FurtherEO,
  title={Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: the Hypertension Genetic Epidemiology Network (HyperGEN) Study.},
  author={James S. Pankow and Diane Marie Dunn and Steven C. Hunt and Mark F. Leppert and Michael B. Miller and D. Chandrasekhra Rao and Gerardo Heiss and Albert Oberman and J. -M. Lalouel and Robert B Weiss},
  journal={American journal of hypertension},
  year={2005},
  volume={18 5 Pt 1},
  pages={672-8}
}
BACKGROUND Postural change in systolic blood pressure (SBP) is prospectively associated with several disease outcomes including hypertension, stroke, and coronary heart disease. The objective of this study was to characterize further a possible quantitative trait locus on chromosome 18q21 influencing SBP response to a postural challenge. METHODS A prior genome scan of postural SBP response in 636 subjects of white ethnicity from 285 hypertensive sibships in the Hypertension Genetic… CONTINUE READING

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