Further evidence for the rejuvenating effects of the dipeptide L-carnosine on cultured human diploid fibroblasts.

@article{McFarland1999FurtherEF,
  title={Further evidence for the rejuvenating effects of the dipeptide L-carnosine on cultured human diploid fibroblasts.},
  author={Gail A McFarland and Robin Holliday},
  journal={Experimental gerontology},
  year={1999},
  volume={34 1},
  pages={35-45}
}
We have confirmed and extended previous results on the beneficial effects of L-carnosine on growth, morphology, and longevity of cultured human fibroblasts, strains MRC-5 and HFF-1. We have shown that late-passage HFF-1 cells retain a juvenile appearance in medium containing 50 mM carnosine, and revert to a senescent phenotype when carnosine is removed. Switching cells between medium with and without carnosine also switches their phenotype from senescent to juvenile, and the reverse. The exact… CONTINUE READING
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