Further evidence for the likely completeness of the library of solved single domain protein structures.

@article{Skolnick2012FurtherEF,
  title={Further evidence for the likely completeness of the library of solved single domain protein structures.},
  author={Jeffrey Skolnick and Hongyi Zhou and Michal Brylinski},
  journal={The journal of physical chemistry. B},
  year={2012},
  volume={116 23},
  pages={
          6654-64
        }
}
Recent studies questioned whether the Protein Data Bank (PDB) contains all compact, single domain protein structures. Here, we show that all quasi-spherical, QS, random protein structures devoid of secondary structure are in the PDB and are excellent templates for all native PDB proteins up to 250 residues. Because QS templates have a similar global contour as native, TASSER can refine 98% (90%) of those whose TM-score is 0.4 (0.35) to structures greater than or equal to the 0.5 TM-score… CONTINUE READING
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