Further evidence for the interaction of μ- and δ-opioid receptors in the antinociceptive effects of the dual inhibitor of enkephalin catabolism, RB101(S): A spinal c-Fos protein study in the rat under carrageenin inflammation

@article{Guen2003FurtherEF,
  title={Further evidence for the interaction of μ- and δ-opioid receptors in the antinociceptive effects of the dual inhibitor of enkephalin catabolism, RB101(S): A spinal c-Fos protein study in the rat under carrageenin inflammation},
  author={St{\'e}phanie Le Guen and Gw{\'e}na{\"e}lle Catheline and Marie-Claude Fourni{\'e}-Zaluski and Bernard-Pierre Roques and Jaroslava Buritova},
  journal={Brain Research},
  year={2003},
  volume={967},
  pages={106-112}
}
We have previously shown that RB101, a dual inhibitor of enkephalin-degrading enzymes, decreased carrageenin-evoked c-Fos protein expression at the spinal cord level in awake rats. Moreover, we have also shown that c-Fos expression is a useful marker of the possible direct or indirect interactions between neural pathways, such as opioid and cholecystokinin systems. We now investigated the respective roles of the three main types of opioid receptors (mu, delta, or kappa) and their possible… CONTINUE READING