Further evidence for the association between a polymorphism in the promoter region of SLC6A3/DAT1 and ADHD: findings from a sample of adults

@article{Azeredo2014FurtherEF,
  title={Further evidence for the association between a polymorphism in the promoter region of SLC6A3/DAT1 and ADHD: findings from a sample of adults},
  author={Lucas Ara{\'u}jo de Azeredo and Diego Luiz Rovaris and Nina Roth Mota and Evelise Regina Polina and Francine Z Marques and Ver{\^o}nica Contini and Eduardo Schneider Vitola and Paulo da Silva Belmonte-de-Abreu and Luis Augusto Rohde and Eugenio Horacio Grevet and Claiton Henrique Dotto Bau},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2014},
  volume={264},
  pages={401-408}
}
The dopamine transporter (SLC6A3/DAT1) plays a key role in the regulation of dopaminergic neurotransmission and is the major site of action for methylphenidate, a first-line medication for attention deficit hyperactivity disorder (ADHD). Most genetic association studies with ADHD have investigated a 40-bp variable number of tandem repeats (VNTR) polymorphism in the 3′-untranslated region (UTR) of the DAT1, but these investigations have reported heterogeneous findings. The few studies focused on… CONTINUE READING
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