Further evidence for null association of phenol sulfotransferase SULT1A1 polymorphism with prostate cancer risk: a case–control study of familial prostate cancer in a Japanese population

@article{Koike2008FurtherEF,
  title={Further evidence for null association of phenol sulfotransferase SULT1A1 polymorphism with prostate cancer risk: a case–control study of familial prostate cancer in a Japanese population},
  author={Hidekazu Koike and Haruki Nakazato and Nobuaki Ohtake and Hiroshi Matsui and Hironobu Okugi and Yasuhiro Shibata and Seiji Nakata and Hidetoshi Yamanaka and Kazuhiro Suzuki},
  journal={International Urology and Nephrology},
  year={2008},
  volume={40},
  pages={947-951}
}
Sulfation is a key pathway in xenobiotic metabolism and chemical defense, and phenol sulfotransferase SULT1A1 plays a central role in this reaction. Genetic polymorphism of the SULT1A1 gene, SULT1A1, was reported to be associated with risks of several cancers; however, one study showed no significant relation between SULT1A1 genotype with prostate cancer risk. The present study was conducted to confirm the association of a G638A polymorphism, Arg213His, in SULT1A1 with familial prostate cancer… CONTINUE READING

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