Further evidence for negative feedback control of serotonin release in the central nervous system

  title={Further evidence for negative feedback control of serotonin release in the central nervous system},
  author={Peter Alexis Baumann and Peter C. Waldmeier},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
In the presence of the serotonin (5-HT) uptake inhibitor citalopram (2×10−5 M), 5-HT, added to the superfusion medium, diminished the electrically induced 3H-overflow from rat cortex slices prelabelled with 3H-5-HT. A 50% decrease of the 3H-overflow was obtained with 6×10−7 M 5-HT. Of the 5-HT antagonists tested (methysergide, methergoline, methiothepin, cyproheptadine, cinanserin, mianserin, pizotifen), methiothepin (50% at 4.5×10−7 M), methergoline (31% at 10−6 M) and cinanserin (30% at 10−6… CONTINUE READING


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