Further evidence for epigenetic influence of MECP2 in Rett, autism and Angelman's syndromes

  title={Further evidence for epigenetic influence of MECP2 in Rett, autism and Angelman's syndromes},
  author={Elena Lopez-Rangel and Mark E. Lewis},
  journal={Clinical Genetics},
The serotonin transporter gene ( SLC 6 A 4 ) shows differential regulation between children with ASD and typically developing children in a South African population
The present study aims to investigate the links between SLC6A4 polymorphisms and complex phenotypes and Autism Spectrum Disorders (ASD), and the challenges of studying ASD: heterogeneity and heritability.
Microbiological Theory of Autism in Childhood
Autism is a syndrome characterized by impairments in social relatedness and communication, repetitive behaviour, abnormal movements, and sensory dysfunction, and boys are four times more likely to have autistic spectrum disorders than girls.
Genetics evaluation for the etiologic diagnosis of autism spectrum disorders
A strategy of a tiered evaluation of the etiology of autism is discussed and recommendations use evidence-based conclusions from the current available literature and cumulative clinical experience.
The Fragile X Family of Disorders: A Model for Autism and Targeted Treatments
The FMR1 gene is causative of a common (autism) phenotype via two entirely different pathogenic mechanisms, RNA toxicity and gene silencing, a paradigm for understanding gene-brain relationships and the means by which diverse genetic mecha- nisms can give rise to a common behavioral phenotype.
Diagnostic yield in the clinical genetic evaluation of autism spectrum disorders
A targeted neurogenetic evaluation of all persons with ASDs seems warranted, and a significant increase in the diagnostic yield reported just a few years ago is found.
Epigenetics of autism spectrum disorders.
The potential role of epigenetic factors in the etiology of ASD is examined, particularly because epigenetic modifications do not change the primary genomic sequence, allowing risk epialleles to evade detection using standard screening strategies.