Corpus ID: 46273595

Further evaluation of diethyldithiocarbamate as an antagonist of cisplatin toxicity.

  title={Further evaluation of diethyldithiocarbamate as an antagonist of cisplatin toxicity.},
  author={G. Gale and L. M. Atkins and E. Walker},
  journal={Annals of clinical and laboratory science},
  volume={12 5},
Diethyldithiocarbamate modulation of murine bone marrow toxicity induced by cis-diammine(cyclobutanedicarboxylato)platinum (II).
The results suggest that the mechanism of DDTC myeloprotection involves stimulation of bone marrow cell proliferation and that the selectivity ofDDTC is based upon the absence of stimulation in tumor cells. Expand
In vitro antitumour and antibacterial studies of some Pt(IV) dithiocarbamate complexes.
A few Pt(IV) complexes of the type [Pt(L)(2)Cl(2)] were synthesized and found to act in monobasic bidentate fashion. Expand
Chemical reactivity of cisplatin bound to human plasma proteins
Human plasma was incubated with cisplatin over 24h and 70% of total platinum reacted with sodiumN,N1-diethyldithiocarbamate, which means that cis platin bound to plasma proteins can — at least in part — still react with strong nucleophiles. Expand
Inhibition of cis-diamminedichloroplatinum (II) — induced renal toxicity in the rat
Treatment with all three dithiocarbamates, NaY, NaG, and DDTC, reduced the intensity of this cellular reaction and also reduced platinum levels in the kidneys, suggesting a persistent cell-mediated immune response to Cis-Pt-induced renal damage. Expand
A Review of the Modulation of Cisplatin Toxicities by Chemoprotectants
For the platinum-based antitumor agents, a large number of thiol-based or sulfur-containing nucleophiles have been tested and several appear to have promise for clinical utility against platinum-induced nephrotoxicity and possibly the peculiar cumulative-dose limiting neuropathy. Expand
Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol.
Administration of EtOH to B6C3F1 mice by gavage produces behavioral changes, changes in blood EtOH levels, and probably glucocorticoid levels representative of at least some human binge drinkers. Expand
Determination of residual free epoxide in polyether polyols by derivatization with diethylammonium N,N-diethyldithiocarbamate and liquid chromatography
A normal-phase liquid chromatographic method is described for the determination of epoxides and particulary residual ethylene oxide and propylene oxide in polyether polyols. The residual epoxides areExpand
Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell line.
Results indicate that oxygen radicals may have a central role to play in the induction of apoptosis and that dithiocarbamates can serve as potent inhibitors of apoptotic bodies induced by a wide variety of stimuli. Expand
Inhibition of cisplatin toxicity without decreasing antitumor efficacy. Use of a dithiocarbamate.
As N-methyl-D-glucaminedithiocarbamate seems to limit morbidity and mortality of high-dose cisplatin administration without decreasing its antitumor efficacy, this drug deserves further investigation in the treatment of cancer. Expand
Dose response and timing effects in the therapy of the LP-BM5 murine retrovirus-induced lymphoproliferative immunodeficiency disease with diethyldithiocarbamate.
Higher doses and a 2-week delayed onset of treatment were generally more effective in reducing the development of lymphadenopathy, hypergammaglobulinemia and in prolonging survival than treatment started on the day of virus inoculation. Expand