Further clinical studies with intrahepatic arterial infusion with 5-fluorouracil.

  title={Further clinical studies with intrahepatic arterial infusion with 5-fluorouracil.},
  author={Fred J. Ansfield and Guillermo Ram{\'i}rez and Hugh L. Davis and G W Wirtanen and Rachel O Johnson and George T. Bryan and F B Manalo and Ernest C. Borden and Thomas E. Davis and M Esmili},
  volume={36 6 Suppl},
A total of 419 patients with progressive liver disease, in nearly all cases metastatic from gastrointestinal primaries, were treated by intrahepatic arterial infusion with 5-FU. Three-fourths of these patients had had prior trials with intravenous 5-FU for 1 or 2 months to several years and had been switched to the infusion upon the development of progression. Catheters were placed percutaneously and the patients infused with 5-FU at a dose of 20 to 30 mg/kg/day X 4, then 15 mg/kg/day X 17, at… CONTINUE READING

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