Further characterization of the time-dependent vascular effects of delta9-tetrahydrocannabinol.

  title={Further characterization of the time-dependent vascular effects of delta9-tetrahydrocannabinol.},
  author={Saoirse Elizabeth O'Sullivan and David A. Kendall and Michael D Randall},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={317 1},
We have previously shown that over time (2 h), the active ingredient of cannabis, Delta(9)-tetrahydrocannabinol (THC), produces peroxisome proliferator-activated receptor (PPAR) gamma-mediated vasorelaxation of conduit arteries. We have now investigated whether incubation with THC affects agonist-stimulated contractile (methoxamine) and endothelium-dependent vasorelaxant (acetylcholine) responses in the rat superior mesenteric artery (G0) and aorta by myography. We have also investigated… CONTINUE READING


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