Further characterization of the gapped DNA intermediates of human spumavirus: evidence for a dual initiation of plus-strand DNA synthesis.

@article{TobalyTapiero1991FurtherCO,
  title={Further characterization of the gapped DNA intermediates of human spumavirus: evidence for a dual initiation of plus-strand DNA synthesis.},
  author={Jo{\"e}lle Tobaly-Tapiero and Jean-Jacques Kupiec and Maud Santillana-Hayat and Martine Canivet and Jorge Peries and Rodica Emanoil-Ravier},
  journal={The Journal of general virology},
  year={1991},
  volume={72 ( Pt 3)},
  pages={605-8}
}
We recently reported the presence of linear duplex DNA intermediates with a gap in the middle of the molecules in the replicative cycle of human (HSRV) and simian (SFV1) spumaviruses. The polypurine tract (PPT), at the 5' boundary of the 3' long terminal repeat, was found to be duplicated in the gap region. By molecular analysis of HSRV proviral DNA with region- and strand-specific probes, we have now determined that the gap is located on plus-strand DNA and that it is 120 bases long with the 3… CONTINUE READING

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