Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction.

@article{Qin2005FurtherCO,
  title={Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction.},
  author={Xuebin Qin and Martin Dobarro and Sylvia J. Bedford and Sean P. Ferris and Patricia Vivian Miranda and Wenping Song and Roderick Terry Bronson and Pablo E Visconti and Jose A Halperin},
  journal={Journal of immunology},
  year={2005},
  volume={175 10},
  pages={6294-302}
}
CD59 is a GPI-linked membrane protein that inhibits formation of the membrane attack complex of complement. We reported recently that mice have two CD59 genes (termed mCd59a and mCd59b), and that the targeted deletion of mCd59b (mCd59b-/-) results in spontaneous hemolytic anemia and progressive loss of male fertility. Further studies of the reproductive abnormalities in mCd59b-/- mice reported in this study revealed the presence of abnormal multinucleated cells and increased apoptotic cells… CONTINUE READING