Further characterization and high-resolution mapping of quantitative trait loci for ethanol-induced locomotor activity.

@article{Demarest2001FurtherCA,
  title={Further characterization and high-resolution mapping of quantitative trait loci for ethanol-induced locomotor activity.},
  author={Kristin Demarest and J Koyner and James A McCaughran and Laura Cipp and Robert Hitzemann},
  journal={Behavior genetics},
  year={2001},
  volume={31 1},
  pages={79-91}
}
Differential sensitivity to the stimulant effects of ethanol on locomotor activity is determined in part by genetic differences. Among inbred strains of mice, moderate doses of ethanol (1-2 g/kg) stimulate locomotor activity in some strains, e.g., the DBA/2J (D2), but only mildly affect activity in other strains, e.g., C57BL/6J (B6) (Crabbe et al., 1982, 1983; Crabbe, 1986; Dudek and Phillips, 1990; Dudek et al., 1991; Dudek and Tritto, 1994). Quantitative trait loci (QTL) for the acute ethanol… CONTINUE READING