Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination

@article{Tavecchio2011FurtherCO,
  title={Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination},
  author={Michele Tavecchio and Joanne M. Munck and C{\'e}line Cano and David R. Newell and Nicola J Curtin},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2011},
  volume={69},
  pages={155-164}
}
Inhibition of DNA repair is emerging as a new therapeutic strategy for cancer treatment. One promising target is DNA-PK, a pivotal kinase in double-strand break repair. The purpose of this study was to further characterise the activity of the DNA-PK inhibitor NU7441, giving some new insights into the biology of DNA-PK. We used NU7441, a potent DNA-PK inhibitor, to evaluate potential pharmacodynamic markers of DNA-PK inhibition, inhibition of DNA repair and chemo- and radio-potentiation in… CONTINUE READING
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