Further brominated bis- and tris-indole alkaloids from the deep-water New Caledonian marine sponge Orina Sp.

@article{Bifulco1995FurtherBB,
  title={Further brominated bis- and tris-indole alkaloids from the deep-water New Caledonian marine sponge Orina Sp.},
  author={Giuseppe Bifulco and Ines Bruno and Raffaele Riccio and Jacques Lavayre and G Bourdy},
  journal={Journal of natural products},
  year={1995},
  volume={58 8},
  pages={
          1254-60
        }
}
Two tris-indole alkaloids, (+/-) gelliusines A and B [1], have been isolated for the first time from a marine source, the New Caledonian sponge, Orina sp. (or Gellius sp.), along with five further indole constituents [2-6]. Compound 6 has been identified as 2,2-bis-(6'-bromo-3'-indolyl(-ethylamine, previously isolated from the tunicate Didemnum candidum, but the remaining four indoles [2-5] are novel compounds. These showed anti-serotonin activity and a strong affinity for somatostatin and… Expand
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