Further-attenuated measles vaccine: virus passages affect viral surface protein expression, immunogenicity and histopathology pattern in vivo.

@article{Sinitsyna1990FurtherattenuatedMV,
  title={Further-attenuated measles vaccine: virus passages affect viral surface protein expression, immunogenicity and histopathology pattern in vivo.},
  author={O. Sinitsyna and O. E. Khudaverdyan and L. Steinberg and F. G. Nagieva and V. Lotte and L. V. Dorofeeva and E. E. Rozina and Boriskin YuS},
  journal={Research in virology},
  year={1990},
  volume={141 5},
  pages={
          517-31
        }
}
Measles vaccine viruses Leningrad-16 (L-16) and Moscow-5 (M-5, an L-16-derived clonal variant), at passage levels used for vaccination and after ten further low-multiplicity passages on quail embryo (QE) cells, were compared for (1) immunogenicity, (2) histopathological lesions induced in vivo and (3) surface protein expression within infected cells and on the virion surface. At the 10th passage, viruses evoked a poorer neutralizing antibody response in guinea pigs, induced an earlier… Expand
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