Further approaches for optimizing polysaccharide-protein conjugate vaccines for prevention of invasive bacterial disease.

@article{Jennings1992FurtherAF,
  title={Further approaches for optimizing polysaccharide-protein conjugate vaccines for prevention of invasive bacterial disease.},
  author={Harold J. Jennings},
  journal={The Journal of infectious diseases},
  year={1992},
  volume={165 Suppl 1},
  pages={
          S156-9
        }
}
The design of conjugate vaccines to optimize their immunologic performance has not been studied extensively. Immunologic performance in relation to changing specific structural parameters in a conjugate can most effectively be analyzed using conjugate syntheses involving terminally activated polysaccharide fragments. Random activation of fragments before conjugation results in more complex and poorly defined conjugates. This is especially true when the length of polysaccharide fragments in… CONTINUE READING

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