Further analysis of the effects of immunotoxic lesions of the basal nucleus of Meynert reveals substantial impairment on visual discrimination learning in monkeys

@article{Ridley2005FurtherAO,
  title={Further analysis of the effects of immunotoxic lesions of the basal nucleus of Meynert reveals substantial impairment on visual discrimination learning in monkeys},
  author={Rosalind M. Ridley and Harry F. Baker and Alicia Leow-Dyke and Rosalyn M. Cummings},
  journal={Brain Research Bulletin},
  year={2005},
  volume={65},
  pages={433-442}
}
ong-term effects of selective immunolesions of cholinergic neurons of the ucleus basalis magnocellularis on the ascending cholinergic pathways in the at : A model for Alzheimer ’ s disease
TLDR
It is demonstrated that, similarly to the very extensive reduction in the number of ChAT-positive neurons in the nBM, cortical areas Fr1 and HL underwent long-lasting reductions in thenumber of AChE-positive fibers in response to specific cholinergic lesioning of the n BM.
The septo-hippocampal system, learning and recovery of function
Effects of nucleus basalis magnocellularis stimulation on a socially transmitted food preference and c-Fos expression.
TLDR
Findings indicate that pretraining NBM electrical stimulation facilitates the acquisition of STFP, supporting a role of NBM in the early stages of memory formation, and suggest that the treatment might cause such effects by inducing neural changes, related to transcription factors such as c-Fos, in the prefrontal cortex or the hippocampal formation.
Basal forebrain activation controls contrast sensitivity in primary visual cortex
TLDR
It is concluded that BF activation has a strong influence on contrast sensitivity in V1 and suggested that, in addition to cholinergic modulation, the BF GABAergic projections play a crucial role in the impact of BF DBS on cortical activity.
Nerve Growth Factor Differentially Affects Spatial and Recognition Memory in Aged Rats
TLDR
Treatment with NGF induced decline of object discrimination in both age-groups and NGF was able to improve spatial memory in aged rats, but had no effect in young controls, confer on NGF potential role in improving spatial but not episodic memory inaged rats.
The marmoset monkey as a model for visual neuroscience
Learning and generalization deficits in patients with memory impairments due to anterior communicating artery aneurysm rupture or hypoxic brain injury.
TLDR
A difference in feedback-based learning is highlighted in 2 amnesic etiologies, despite similar levels of declarative memory impairment.
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Different effects on learning ability after injection of the cholinergic immunotoxin ME20.4IgG-saporin into the diagonal band of Broca, basal nucleus of Meynert, or both in monkeys.
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The impairment after NBM lesions ameliorated with time but could be reinstated by a low dose of the glutamate blocking drug MK801, which, at this dose, did not impair simple visual discrimination learning in normal monkeys.
Unilateral lesions of the cholinergic basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys.
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The results of the present study provide a novel link between the mechanisms of medial temporal lobe amnesia and Alzheimer's disease in which the cholinergic basal forebrain shows pathology.
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Crossed unilateral lesions of temporal lobe structures and cholinergic cell bodies impair visual conditional and object discrimination learning in monkeys
TLDR
It is argued that intact IT cortex in only one hemisphere is sufficient to sustain simple visual discrimination learning but implies that the cholinergic input and the inferotemporal cortical input to the hippocampus both contribute to visual conditional learning.
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