Further Studies on the Hypothesis of PARP-1 Inhibition as a Strategy for Lessening the Long-Term Effects Produced by Perinatal Asphyxia: Effects of Nicotinamide and Theophylline on PARP-1 Activity in Brain and Peripheral Tissue

@article{AllendeCastro2012FurtherSO,
  title={Further Studies on the Hypothesis of PARP-1 Inhibition as a Strategy for Lessening the Long-Term Effects Produced by Perinatal Asphyxia: Effects of Nicotinamide and Theophylline on PARP-1 Activity in Brain and Peripheral Tissue},
  author={Camilo Allende-Castro and Pablo Espina-Marchant and Diego A. Bustamante and Edgardo Rojas-Mancilla and Tanya Neira and Manuel A. Guti{\'e}rrez-Hern{\'a}ndez and Daniela Esmar and Jos{\'e} L Vald{\'e}s and Paola Morales and Peter J. Gebicke-Haerter and Mario Herrera-Marschitz},
  journal={Neurotoxicity Research},
  year={2012},
  volume={22},
  pages={79-90}
}
Oxygen interruption leads to death when re-oxygenation is not promptly re-established. Re-oxygenation triggers a cascade of biochemical events for restoring function at the cost of improper homeostasis. The effects observed long after perinatal asphyxia (PA) have been explained by over-expression of sentinel proteins, such as poly(ADP-ribose) polymerase-1 (PARP-1), competing for NAD+ during re-oxygenation, leading to the idea that sentinel protein inhibition constitutes a therapeutic strategy… CONTINUE READING