Further Characterization of the Discriminative Stimulus Effects of Spiradoline

@article{Holtzman2000FurtherCO,
  title={Further Characterization of the Discriminative Stimulus Effects of Spiradoline},
  author={Stephen G. Holtzman},
  journal={Pharmacology Biochemistry and Behavior},
  year={2000},
  volume={66},
  pages={517-522}
}
  • S. Holtzman
  • Published 1 July 2000
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
The results of a previous study in rats indicated that spiradoline has pharmacologically selective discriminative effects that are mediated by kappa-opioid receptors. However, the training dose, 3.0 mg/kg, increased response latencies, suggesting that it was relatively high. The current study was performed to characterize further the discriminative effects of spiradoline by using a lower training dose, 1.0 mg/kg, and testing a larger number of drugs for generalization with spiradoline. Rats… 
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