Furosemide-sensitive Na and K fluxes in human red cells. Net uphill Na extrusion and equilibrium properties.

@article{Brugnara1986FurosemidesensitiveNA,
  title={Furosemide-sensitive Na and K fluxes in human red cells. Net uphill Na extrusion and equilibrium properties.},
  author={Carlo Brugnara and M Aurora Canessa and Daniele Cusi and Daniel C. Tosteson},
  journal={The Journal of general physiology},
  year={1986},
  volume={87 1},
  pages={
          91-112
        }
}
This paper reports experiments designed to find the concentrations of internal and external Na and K at which inward and outward furosemide-sensitive (FS) Na and K fluxes are equal, so that there is no net FS movement of Na and K. The red cell cation content was modified by using the ionophore nystatin, varying cell Na (Nai) from 0 to 34 mM (K substitution, high-K cells) and cell K (Ki) from 0 to 30 mM (Na substitution, high-Na cells). All incubation media contained NaCl (Nao = 130 or 120 nM… CONTINUE READING

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