Furosemide ototoxicity: clinical and experimental aspects.

  title={Furosemide ototoxicity: clinical and experimental aspects.},
  author={Leonard P Rybak},
  journal={The Laryngoscope},
  volume={95 9 Pt 2 Suppl 38},
Furosemide is an ototoxic diuretic. Furosemide injection is followed by a rapid, but reversible decrease of the endocochlear potential and eighth nerve action potential with a more gradual decrease of the endolymph potassium concentration. In contrast to the reversible effects of furosemide alone on the cochlea, the combination of kanamycin with furosemide resulted in irreversible changes in cochlear function which were associated with elevated levels of kanamycin in the blood and perilymph of… CONTINUE READING


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